BDBM50148709 (5-(3-amino-3-methylbut-1-ynyl)-2-methoxyphenyl)(4-(2,4-difluorophenylamino)phenyl)methanone::CHEMBL419409::[5-(3-Amino-3-methyl-but-1-ynyl)-2-methoxy-phenyl]-[4-(2,4-difluoro-phenylamino)-phenyl]-methanone

SMILES COc1ccc(cc1C(=O)c1ccc(Nc2ccc(F)cc2F)cc1)C#CC(C)(C)N

InChI Key InChIKey=RCXVRYYLBZGIFP-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50148709   

TargetEpidermal growth factor receptor(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50148709((5-(3-amino-3-methylbut-1-ynyl)-2-methoxyphenyl)(4...)
Affinity DataIC50: 4.40E+3nMAssay Description:Inhibition of human Epidermal growth factor receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2012
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50148709((5-(3-amino-3-methylbut-1-ynyl)-2-methoxyphenyl)(4...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of human cytochrome P450 1A2More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2012
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50148709((5-(3-amino-3-methylbut-1-ynyl)-2-methoxyphenyl)(4...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of human cytochrome P450 3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2012
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50148709((5-(3-amino-3-methylbut-1-ynyl)-2-methoxyphenyl)(4...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of human cytochrome P450 2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50148709((5-(3-amino-3-methylbut-1-ynyl)-2-methoxyphenyl)(4...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibit of human c-Jun N-terminal kinase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Mouse)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50148709((5-(3-amino-3-methylbut-1-ynyl)-2-methoxyphenyl)(4...)
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of murine His-Mitogen-activated protein kinase p38 alpha phosphorylation.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2012
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50148709((5-(3-amino-3-methylbut-1-ynyl)-2-methoxyphenyl)(4...)
Affinity DataIC50: 8.80E+3nMAssay Description:Inhibition of human Epidermal growth factor receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2012
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50148709((5-(3-amino-3-methylbut-1-ynyl)-2-methoxyphenyl)(4...)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibit of human Met proto-oncogene tyrosine kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2012
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50148709((5-(3-amino-3-methylbut-1-ynyl)-2-methoxyphenyl)(4...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of human cytochrome P450 2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2012
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50148709((5-(3-amino-3-methylbut-1-ynyl)-2-methoxyphenyl)(4...)
Affinity DataIC50: 8.00E+4nMAssay Description:Inhibition of human prostaglandin G/H synthase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50148709((5-(3-amino-3-methylbut-1-ynyl)-2-methoxyphenyl)(4...)
Affinity DataIC50: 14nMAssay Description:Inhibition of P38alphaMAPK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed