BDBM50148183 CHEMBL3764377

SMILES OC(=O)CN(Cc1cccc(c1)-c1ccccc1OC(F)(F)F)S(=O)(=O)c1ccc(OC(F)F)cc1

InChI Key InChIKey=UJIVGLYKHVAGFS-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50148183   

TargetCytochrome P450 2C19(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50148183(CHEMBL3764377)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using (S)-mephenytoin as substrate incubated for 5 mins by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2017
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50148183(CHEMBL3764377)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate incubated for 7 mins by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2017
Entry Details Article
PubMed
TargetDiacylglycerol lipase-alpha(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50148183(CHEMBL3764377)
Affinity DataIC50: 60nMAssay Description:Inhibition of full length human C-terminal HA-tagged DAGLalpha expressed in HEK293 cells using DAG as substrate assessed as reduction in intracellula...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2017
Entry Details Article
PubMed
TargetDiacylglycerol lipase-alpha(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50148183(CHEMBL3764377)
Affinity DataIC50: 17nMAssay Description:Inhibition of full length human C-terminal HA-tagged DAGLalpha expressed in HEK293 cell membrane using DAG as substrate incubated for 20 mins by LC-M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2017
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50148183(CHEMBL3764377)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of human ERG expressed in HEK293 cells by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2017
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50148183(CHEMBL3764377)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate incubated for 10 mins by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2017
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50148183(CHEMBL3764377)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate incubated for 5 mins by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2017
Entry Details Article
PubMed