BDBM50147473 3-(2-Chloro-phenyl)-4-[1-(3-hydroxy-propyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-pyrrole-2,5-dione::CHEMBL326971

SMILES OCCCn1cc(C2=C(C(=O)NC2=O)c2ccccc2Cl)c2cccnc12

InChI Key InChIKey=CAGLPTUMBKISRZ-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50147473   

TargetProtein kinase C alpha type(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50147473(3-(2-Chloro-phenyl)-4-[1-(3-hydroxy-propyl)-1H-pyr...)
Affinity DataIC50: 4.40E+3nMAssay Description:Inhibitory concentration against protein kinase C-alpha using histone as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProtein kinase C gamma type(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50147473(3-(2-Chloro-phenyl)-4-[1-(3-hydroxy-propyl)-1H-pyr...)
Affinity DataIC50: 5.50E+3nMAssay Description:Inhibition of protein kinase C-gammaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProtein kinase C beta type(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50147473(3-(2-Chloro-phenyl)-4-[1-(3-hydroxy-propyl)-1H-pyr...)
Affinity DataIC50: 730nMAssay Description:Inhibitory concentration against human protein kinase C-betaII using histone as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50147473(3-(2-Chloro-phenyl)-4-[1-(3-hydroxy-propyl)-1H-pyr...)
Affinity DataIC50: 10nMAssay Description:Inhibitory concentration against rabbit glycogen synthase kinase-3 beta using protein phosphatase inhibitor-2 as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50147473(3-(2-Chloro-phenyl)-4-[1-(3-hydroxy-propyl)-1H-pyr...)
Affinity DataIC50: 10nMAssay Description:Inhibition of full length recombinant His-tagged human Glycogen synthase kinase-3 beta expressed in Baculovirus expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed