BDBM50147463 3-(3-Chloro-5-trifluoromethyl-pyridin-2-yl)-4-[1-(3-hydroxy-propyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-pyrrole-2,5-dione::CHEMBL111620

SMILES OCCCn1cc(C2=C(C(=O)NC2=O)c2ncc(cc2Cl)C(F)(F)F)c2cccnc12

InChI Key InChIKey=WFTBLYUVDBPJAV-UHFFFAOYSA-N

Data  6 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50147463   

TargetGlycogen synthase kinase-3 beta(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50147463(3-(3-Chloro-5-trifluoromethyl-pyridin-2-yl)-4-[1-(...)
Affinity DataIC50: 26nMAssay Description:Inhibitory concentration against rabbit glycogen synthase kinase-3 beta using protein phosphatase inhibitor-2 as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50147463(3-(3-Chloro-5-trifluoromethyl-pyridin-2-yl)-4-[1-(...)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of Cyclin-dependent kinase 2-cyclin AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50147463(3-(3-Chloro-5-trifluoromethyl-pyridin-2-yl)-4-[1-(...)
Affinity DataIC50: 5.80E+3nMAssay Description:Inhibition of Cyclin-dependent kinase 1-cyclin BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50147463(3-(3-Chloro-5-trifluoromethyl-pyridin-2-yl)-4-[1-(...)
Affinity DataEC50:  620nMAssay Description:Effective concentration of compound against glycogen synthase kinase-3 in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-5(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50147463(3-(3-Chloro-5-trifluoromethyl-pyridin-2-yl)-4-[1-(...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of MSK-1 kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50147463(3-(3-Chloro-5-trifluoromethyl-pyridin-2-yl)-4-[1-(...)
Affinity DataIC50: 26nMAssay Description:Inhibition of GSK-3beta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/30/2020
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50147463(3-(3-Chloro-5-trifluoromethyl-pyridin-2-yl)-4-[1-(...)
Affinity DataIC50: 26nMAssay Description:Inhibition of full length recombinant His-tagged human Glycogen synthase kinase-3 beta expressed in Baculovirus expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed