BDBM50146029 CHEMBL3764383

SMILES CC(C)[C@@H](C)n1cc(-c2ccc(cn2)N2CCOCC2)c2[nH]nc(N)c2c1=O

InChI Key InChIKey=NAGJVNORNVHZDU-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50146029   

TargetTyrosine-protein kinase JAK3(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50146029(CHEMBL3764383)
Affinity DataIC50: 85nMAssay Description:Inhibition of JAK3 (unknown origin) using Ulight-JAK1 substrate peptide assessed as reduction in ATP-dependent substrate phosphorylation after 45 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50146029(CHEMBL3764383)
Affinity DataIC50: 140nMAssay Description:Inhibition of JAK2 (unknown origin) using Ulight-JAK1 substrate peptide assessed as reduction in ATP-dependent substrate phosphorylation after 45 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50146029(CHEMBL3764383)
Affinity DataIC50: 100nMAssay Description:Inhibition of JAK1 (unknown origin) using Ulight-JAK1 substrate peptide assessed as reduction in ATP-dependent substrate phosphorylation after 45 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2017
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50146029(CHEMBL3764383)
Affinity DataIC50: 9.70nMAssay Description:Inhibition of recombinant human TYK2 kinase domain (885-1176 residues) using Ulight-JAK1 substrate peptide assessed as reduction in ATP-dependent sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2017
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50146029(CHEMBL3764383)
Affinity DataIC50: 440nMAssay Description:Inhibition of TYK2 in human Jurkat cells assessed as reduction in IL-23-induced luciferase gene expression after 24 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2017
Entry Details Article
PubMed