BDBM50145657 CHEBI:47069::CHEMBL412813

SMILES N[C@@H](Cc1ccc(Cl)cc1)C(O)=O

InChI Key InChIKey=NIGWMJHCCYYCSF-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50145657   

TargetTryptophan 5-hydroxylase 1(Human)
Karos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50145657(CHEBI:47069 | CHEMBL412813)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of TPH1 (unknown origin) using L-tyrosine as substrate after 20 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2017
Entry Details Article
PubMed
TargetTryptophan 5-hydroxylase 1(Human)
Karos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50145657(CHEBI:47069 | CHEMBL412813)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of Tryptophan hydroxylase 1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetTryptophan 5-hydroxylase 1(Human)
Karos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50145657(CHEBI:47069 | CHEMBL412813)
Affinity DataIC50: 1.98E+4nMAssay Description:Inhibition of N-terminal MBP-tagged full length human TPH1 assessed as reduction in 5-HTP formation incubated for 5 to 10 mins by fluorescence microp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTryptophan 5-hydroxylase 2(Human)
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)

Curated by ChEMBL
LigandPNGBDBM50145657(CHEBI:47069 | CHEMBL412813)
Affinity DataIC50: 2.17E+4nMAssay Description:Inhibition of N-terminal MBP-tagged full length human TPH2 assessed as reduction in 5-HTP formation incubated for 5 to 10 mins by fluorescence microp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed