BDBM50144810 7-Chloro-3-hydroxy-6-nitro-1H-quinazoline-2,4-dione::CHEMBL432748

SMILES On1c(=O)[nH]c2cc(Cl)c(cc2c1=O)[N+]([O-])=O

InChI Key InChIKey=IMEHGFVLYXZUAZ-UHFFFAOYSA-N

Data  5 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50144810   

TargetCarbonic anhydrase 9(Human)
Universita Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM50144810(7-Chloro-3-hydroxy-6-nitro-1H-quinazoline-2,4-dion...)
Affinity DataKi:  7.90nMAssay Description:Inhibition of recombinant human carbonic anhydrase 9 preincubated for 15 mins prior to testing by phenol red based stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2019
Entry Details Article
PubMed
TargetCarbonic anhydrase 12(Human)
Universita Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM50144810(7-Chloro-3-hydroxy-6-nitro-1H-quinazoline-2,4-dion...)
Affinity DataKi:  8nMAssay Description:Inhibition of recombinant human carbonic anhydrase 12 preincubated for 15 mins prior to testing by phenol red based stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2019
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1(Rat)
Universita Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM50144810(7-Chloro-3-hydroxy-6-nitro-1H-quinazoline-2,4-dion...)
Affinity DataKi:  1.10E+3nMAssay Description:Ability of compound to displace [3H]glycine from N-methyl-D-aspartate glutamate receptor 1 from in cerebral cortex synaptic membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Universita Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM50144810(7-Chloro-3-hydroxy-6-nitro-1H-quinazoline-2,4-dion...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of recombinant human carbonic anhydrase 1 preincubated for 15 mins prior to testing by phenol red based stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2019
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Universita Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM50144810(7-Chloro-3-hydroxy-6-nitro-1H-quinazoline-2,4-dion...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of recombinant human carbonic anhydrase 2 preincubated for 15 mins prior to testing by phenol red based stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2019
Entry Details Article
PubMed