BDBM50144760 (S)-2-{[(S)-1-Benzenesulfonyl-N-(2,2,2-trifluoro-ethyl)-azetidine-2-carboximidoyl]-amino}-3-(2',6'-dimethoxy-biphenyl-4-yl)-propionic acid::CHEMBL306827

SMILES COc1cccc(OC)c1-c1ccc(C[C@H](N=C(NCC(F)(F)F)[C@@H]2CCN2S(=O)(=O)c2ccccc2)C(O)=O)cc1

InChI Key InChIKey=DHLWZPYEINGBFR-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50144760   

TargetIntegrin alpha-4/beta-7(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50144760((S)-2-{[(S)-1-Benzenesulfonyl-N-(2,2,2-trifluoro-e...)
Affinity DataIC50: 27nMAssay Description:Inhibitory activity of compound against alpha4-beta7 integrin using MAdCAM-Ig ligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-4/beta-1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50144760((S)-2-{[(S)-1-Benzenesulfonyl-N-(2,2,2-trifluoro-e...)
Affinity DataIC50: 0.130nMAssay Description:Displacement of 125I-VCAM-Ig from VLA4 in human Jurkat cells incubated for 30 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed