BDBM50143750 (2,4-Dimethyl-1-oxy-pyridin-3-yl)-(4-diphenylamino-4'-methyl-[1,4']bipiperidinyl-1'-yl)-methanone::CHEMBL556314

SMILES Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(C)(CC1)N1CCC(CC1)N(c1ccccc1)c1ccccc1

InChI Key InChIKey=KFDHCUNXEPNTLZ-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50143750   

TargetC-C chemokine receptor type 5(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50143750((2,4-Dimethyl-1-oxy-pyridin-3-yl)-(4-diphenylamino...)
Affinity DataIC50: 3.30nMAssay Description:Antagonistic activity against human C-C chemokine receptor type 5.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 5(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50143750((2,4-Dimethyl-1-oxy-pyridin-3-yl)-(4-diphenylamino...)
Affinity DataIC50: 3.40nMAssay Description:Antagonistic activity against monkey C-C chemokine receptor type 5.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 5(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50143750((2,4-Dimethyl-1-oxy-pyridin-3-yl)-(4-diphenylamino...)
Affinity DataIC50: 16nMAssay Description:Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 5(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50143750((2,4-Dimethyl-1-oxy-pyridin-3-yl)-(4-diphenylamino...)
Affinity DataIC50: 3.30nMAssay Description:Displacement of [125I]RANTES from human CCR5 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetC-C chemokine receptor type 5(Crab-eating macaque)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50143750((2,4-Dimethyl-1-oxy-pyridin-3-yl)-(4-diphenylamino...)
Affinity DataIC50: 3.40nMAssay Description:Displacement of radiolabeled MIP-1alpha from cynomolgus monkey CCR5 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed