BDBM50143610 6-amino-20-cyclobutylmethyl-(1R,12S)-7-thia-5,20-diazapentacyclo[10.5.3.01,13.02,10.04,8]icosa-2(10),3,5,8-tetraen-11-one::CHEMBL299713

SMILES Nc1nc2cc3c(cc2s1)C(=O)[C@@H]1C2CCCC[C@]32CCN1CC1CCC1

InChI Key

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50143610   

TargetKappa-type opioid receptor(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50143610(6-amino-20-cyclobutylmethyl-(1R,12S)-7-thia-5,20-d...)
Affinity DataKi:  13nMAssay Description:Agonistic activity against kappa opioid receptor in Chinese hamster ovary membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50143610(6-amino-20-cyclobutylmethyl-(1R,12S)-7-thia-5,20-d...)
Affinity DataKi:  200nMAssay Description:Inhibition of [3H]-DAMGO binding to Opioid receptor mu 1 of Chinese hamster ovary membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50143610(6-amino-20-cyclobutylmethyl-(1R,12S)-7-thia-5,20-d...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of [3H]naltrindole binding to opioid receptor delta 1 of Chinese hamster ovary membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed