BDBM50143090 3-Phenyl-6-(pyridin-2-ylmethoxy)-7,8,9,10-tetrahydro-[1,2,4]triazolo[3,4-a]phthalazine::CHEMBL53238

SMILES C(Oc1nn2c(nnc2c2CCCCc12)-c1ccccc1)c1ccccn1

InChI Key InChIKey=ZPSBXQBYCQOCEU-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50143090   

TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50143090(3-Phenyl-6-(pyridin-2-ylmethoxy)-7,8,9,10-tetrahyd...)
Affinity DataKi:  0.380nMAssay Description:Binding affinity for human GABA-A receptor alpha-5-beta-3-gamma-2 subunits in L(tk-) cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50143090(3-Phenyl-6-(pyridin-2-ylmethoxy)-7,8,9,10-tetrahyd...)
Affinity DataKi:  0.850nMAssay Description:Binding affinity for human GABA-A receptor alpha-3-beta-3-gamma-2 subunits in L(tk-) cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50143090(3-Phenyl-6-(pyridin-2-ylmethoxy)-7,8,9,10-tetrahyd...)
Affinity DataKi:  1.90nMAssay Description:Binding affinity for human GABA-A receptor alpha-2-beta-3-gamma-2 subunits in L(tk-) cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50143090(3-Phenyl-6-(pyridin-2-ylmethoxy)-7,8,9,10-tetrahyd...)
Affinity DataKi:  4.30nMAssay Description:Binding affinity for human GABA-A receptor alpha-4-beta-3-gamma-2 subunits in L(tk-) cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed