BDBM50143089 6-(5-Methyl-pyridin-2-ylmethoxy)-3-phenyl-[1,2,4]triazolo[3,4-a]phthalazine::CHEMBL300497

SMILES Cc1ccc(COc2nn3c(nnc3c3ccccc23)-c2ccccc2)nc1

InChI Key InChIKey=IVVHFTRDYKTGCC-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50143089   

TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50143089(6-(5-Methyl-pyridin-2-ylmethoxy)-3-phenyl-[1,2,4]t...)
Affinity DataKi:  1.10nMAssay Description:Binding affinity for human GABA-A receptor alpha-5-beta-3-gamma-2 subunits in L(tk-) cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50143089(6-(5-Methyl-pyridin-2-ylmethoxy)-3-phenyl-[1,2,4]t...)
Affinity DataKi:  3.60nMAssay Description:Binding affinity for human GABA-A receptor alpha-2-beta-3-gamma-2 subunits in L(tk-) cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50143089(6-(5-Methyl-pyridin-2-ylmethoxy)-3-phenyl-[1,2,4]t...)
Affinity DataKi:  4.30nMAssay Description:Binding affinity for human GABA-A receptor alpha-3-beta-3-gamma-2 subunits in L(tk-) cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50143089(6-(5-Methyl-pyridin-2-ylmethoxy)-3-phenyl-[1,2,4]t...)
Affinity DataKi:  4.80nMAssay Description:Binding affinity for human GABA-A receptor alpha-4-beta-3-gamma-2 subunits in L(tk-) cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed