BDBM50142885 Benzyl-[1-(2-chloro-2-phenyl-ethyl)-6-methylsulfanyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl]-amine::CHEMBL288280::N-benzyl-1-(2-chloro-2-phenylethyl)-6-(methylthio)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

SMILES CSc1nc(NCc2ccccc2)c2cnn(CC(Cl)c3ccccc3)c2n1

InChI Key InChIKey=VRYGLOHNGHJHFM-UHFFFAOYSA-N

Data  11 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50142885   

TargetTyrosine-protein kinase ABL1(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50142885(N-benzyl-1-(2-chloro-2-phenylethyl)-6-(methylthio)...)
Affinity DataKi:  260nMAssay Description:Inhibition of human recombinant AblMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50142885(N-benzyl-1-(2-chloro-2-phenylethyl)-6-(methylthio)...)
Affinity DataKi:  260nMAssay Description:Inhibition of human recombinant c-Abl by filter-binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50142885(N-benzyl-1-(2-chloro-2-phenylethyl)-6-(methylthio)...)
Affinity DataKi:  260nMAssay Description:Inhibition human recombinant Abl using Abtide peptide substrate in presence of [gamma-32P]-ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50142885(N-benzyl-1-(2-chloro-2-phenylethyl)-6-(methylthio)...)
Affinity DataKi:  300nMAssay Description:Inhibition of human recombinant Abl by filter-binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50142885(N-benzyl-1-(2-chloro-2-phenylethyl)-6-(methylthio)...)
Affinity DataKi:  3.70E+3nMAssay Description:Inhibitory activity against Src in cell free assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50142885(N-benzyl-1-(2-chloro-2-phenylethyl)-6-(methylthio)...)
Affinity DataKi:  3.70E+3nMAssay Description:Inhibition of human recombinant SrcMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50142885(N-benzyl-1-(2-chloro-2-phenylethyl)-6-(methylthio)...)
Affinity DataKi:  3.70E+3nMAssay Description:Inhibition of human recombinant c-Src by filter-binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50142885(N-benzyl-1-(2-chloro-2-phenylethyl)-6-(methylthio)...)
Affinity DataKi:  3.70E+3nMAssay Description:Inhibition of human recombinant SrcMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50142885(N-benzyl-1-(2-chloro-2-phenylethyl)-6-(methylthio)...)
Affinity DataKi:  3.70E+3nMAssay Description:Inhibition of human recombinant c-Src by filter-binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50142885(N-benzyl-1-(2-chloro-2-phenylethyl)-6-(methylthio)...)
Affinity DataKi:  3.70E+3nMAssay Description:Inhibition human recombinant cSRC using KVEKIGEGTYGVVYK peptide substrate in presence of [gamma-32P]-ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50142885(N-benzyl-1-(2-chloro-2-phenylethyl)-6-(methylthio)...)
Affinity DataKi:  3.98E+3nMAssay Description:Inhibition of c-SrcMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed