BDBM50142448 (S)-1-(3-(3-(4-fluorobenzyl)piperidin-1-yl)propyl)-3-(3-acetylphenyl)urea::1-(3-Acetyl-phenyl)-3-{3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-yl]-propyl}-urea::CHEMBL46905

SMILES CC(=O)c1cccc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1

InChI Key InChIKey=FDDSQKZQCHXOJV-UHFFFAOYSA-N

Data  1 KI  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50142448   

TargetC-C chemokine receptor type 3(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50142448(1-(3-Acetyl-phenyl)-3-{3-[(S)-3-(4-fluoro-benzyl)-...)
Affinity DataIC50: 2.5nMAssay Description:Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetC-C chemokine receptor type 3(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50142448(1-(3-Acetyl-phenyl)-3-{3-[(S)-3-(4-fluoro-benzyl)-...)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 3(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50142448(1-(3-Acetyl-phenyl)-3-{3-[(S)-3-(4-fluoro-benzyl)-...)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of eotaxin-induced chemotaxis of human eosinophilsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 3(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50142448(1-(3-Acetyl-phenyl)-3-{3-[(S)-3-(4-fluoro-benzyl)-...)
Affinity DataIC50: 2.5nMAssay Description:Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 3(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50142448(1-(3-Acetyl-phenyl)-3-{3-[(S)-3-(4-fluoro-benzyl)-...)
Affinity DataIC50: 25nMAssay Description:Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50142448(1-(3-Acetyl-phenyl)-3-{3-[(S)-3-(4-fluoro-benzyl)-...)
Affinity DataIC50: 500nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50142448(1-(3-Acetyl-phenyl)-3-{3-[(S)-3-(4-fluoro-benzyl)-...)
Affinity DataKi:  1.35E+3nMAssay Description:Inhibition of [125I]-eotaxin binding to serotonin 5-hydroxytryptamine 2A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed