BDBM50142083 CHEMBL3758664

SMILES Brc1ccc(cc1)-c1ncc(OCC2CCNCC2)nc1-c1ccc(Br)cc1

InChI Key InChIKey=OVUOVSPMCJKBJA-UHFFFAOYSA-N

Data  1 KI  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50142083   

TargetGenome polyprotein(DENV-2)
Baylor College of Medicine

Curated by ChEMBL
LigandPNGBDBM50142083(CHEMBL3758664)
Affinity DataIC50: 3.50E+4nMAssay Description:Inhibition Dengue serotype-2 NS3B/NS3 protease using 7-amino-4-methylcoumarin as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetNonstructural protein 3(ZIKV)
Baylor College of Medicine

Curated by ChEMBL
LigandPNGBDBM50142083(CHEMBL3758664)
Affinity DataIC50: 2.17E+4nMAssay Description:Inhibition Zika virus NS3B (47 to 95 residues)/NS3 (1 to 170 residues) protease expressed in Escherichia coli BL21 using 7-amino-4-methylcoumarin as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetGenome polyprotein(WNV)
Baylor College of Medicine

Curated by ChEMBL
LigandPNGBDBM50142083(CHEMBL3758664)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition West Nile virus NS3B/NS3 protease using 7-amino-4-methylcoumarin as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetHistone acetyltransferase p300(Human)
Baylor College of Medicine

Curated by ChEMBL
LigandPNGBDBM50142083(CHEMBL3758664)
Affinity DataIC50: 5.70E+3nMAssay Description:Inhibition of human p300 HAT domain (1195 to 1673 residues) using histone H3 peptide and acetyl-coA as substrates preincubated for 10 mins followed b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetHistone acetyltransferase p300(Human)
Baylor College of Medicine

Curated by ChEMBL
LigandPNGBDBM50142083(CHEMBL3758664)
Affinity DataIC50: 2.70E+4nMAssay Description:Inhibition of biotinylated histone H4 peptide binding to His-tagged human p300 HAT domain (1195 to 1673 residues) assessed as reduction in alpha sign...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Baylor College of Medicine

Curated by ChEMBL
LigandPNGBDBM50142083(CHEMBL3758664)
Affinity DataKi:  2.62E+4nMAssay Description:Inhibition of recombinant human GST-tagged LSD1 catalytic domain (172 to 833 residues) using dimethylated H3K4 peptide substrate preincubated for 10 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2017
Entry Details Article
PubMed