BDBM50142026 3-((1-methyl-1H-indol-3-yl)methylene)-1H-pyrrolo[3,2-b]pyridin-2(3H)-one::3-(1-Methyl-1H-indol-3-ylmethylene)-1,3-dihydro-pyrrolo[3,2-b]pyridin-2-one::CHEMBL176544

SMILES Cn1cc(\C=C2/C(=O)Nc3cccnc23)c2ccccc12

InChI Key InChIKey=NXNQLECPAXXYTR-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50142026   

TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50142026(3-(1-Methyl-1H-indol-3-ylmethylene)-1,3-dihydro-py...)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of c-Raf1 kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2012
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50142026(3-(1-Methyl-1H-indol-3-ylmethylene)-1,3-dihydro-py...)
Affinity DataIC50: 2nMAssay Description:Inhibition of receptor Tyrosine kinase A, TrkA (nerve growth factor receptor)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2012
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50142026(3-(1-Methyl-1H-indol-3-ylmethylene)-1,3-dihydro-py...)
Affinity DataIC50: 3nMAssay Description:Inhibition of human N- terminal GST-tagged TrkA cytoplasmic domain (436 to 790 residues) expressed in baculovirus infected sf21 cells using biotinyla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2018
Entry Details Article
PubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50142026(3-(1-Methyl-1H-indol-3-ylmethylene)-1,3-dihydro-py...)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of Cyclin-dependent kinase 2 cyclin AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2012
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50142026(3-(1-Methyl-1H-indol-3-ylmethylene)-1,3-dihydro-py...)
Affinity DataIC50: 2nMAssay Description:Inhibition of GST-fused TrkA (unknown origin) expressed in SF9 cells using H2N-RRRAAAEEIYGEINH2 peptide as substrate preincubated with ATP and Mg and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed