BDBM50141779 2,6-Dimethyl-4-phenyl-1-(4-sulfamoyl-phenyl)-pyridinium; perchlorate::CHEMBL171350::Sulfonamide, 7

SMILES Cc1cc(cc(C)[n+]1-c1ccc(cc1)S(N)(=O)=O)-c1ccccc1

InChI Key InChIKey=ZMWQBWHUMLFNIW-UHFFFAOYSA-N

Data  7 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50141779   

TargetCarbonic anhydrase 2(Human)
UniversitÀ Degli Studi Di Firenze

LigandPNGBDBM50141779(CHEMBL171350 | Sulfonamide, 7 | 2,6-Dimethyl-4-phe...)
Affinity DataKi:  14nM ΔG°:  -10.5kcal/molepH: 7.4 T: 2°CAssay Description:The initial rates of 4-nitrophenylacetate hydrolysis catalysed by different CA isozymes were monitored spectrophotometrically at 400nm with a Cary 3 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 4(Bovine)
UniversitÀ Degli Studi Di Firenze

LigandPNGBDBM50141779(CHEMBL171350 | Sulfonamide, 7 | 2,6-Dimethyl-4-phe...)
Affinity DataKi:  29nM ΔG°:  -10.1kcal/molepH: 7.4 T: 2°CAssay Description:The initial rates of 4-nitrophenylacetate hydrolysis catalysed by different CA isozymes were monitored spectrophotometrically at 400nm with a Cary 3 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 9(Human)
Slovak Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50141779(CHEMBL171350 | Sulfonamide, 7 | 2,6-Dimethyl-4-phe...)
Affinity DataKi:  48nMAssay Description:Inhibitory activity against human carbonic anhydrase IXMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
UniversitÀ Degli Studi Di Firenze

LigandPNGBDBM50141779(CHEMBL171350 | Sulfonamide, 7 | 2,6-Dimethyl-4-phe...)
Affinity DataKi:  60nMAssay Description:Inhibitory activity against human carbonic anhydrase IIMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 4(Bovine)
UniversitÀ Degli Studi Di Firenze

LigandPNGBDBM50141779(CHEMBL171350 | Sulfonamide, 7 | 2,6-Dimethyl-4-phe...)
Affinity DataKi:  211nMAssay Description:Inhibitory activity against carbonic anhydrase IV from bovine lung microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
UniversitÀ Degli Studi Di Firenze

LigandPNGBDBM50141779(CHEMBL171350 | Sulfonamide, 7 | 2,6-Dimethyl-4-phe...)
Affinity DataKi:  250nM ΔG°:  -8.85kcal/molepH: 7.4 T: 2°CAssay Description:The initial rates of 4-nitrophenylacetate hydrolysis catalysed by different CA isozymes were monitored spectrophotometrically at 400nm with a Cary 3 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
UniversitÀ Degli Studi Di Firenze

LigandPNGBDBM50141779(CHEMBL171350 | Sulfonamide, 7 | 2,6-Dimethyl-4-phe...)
Affinity DataKi:  7.00E+3nMAssay Description:Inhibitory activity against human carbonic anhydrase IMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2012
Entry Details Article
PubMed