BDBM50140901 6-(4-chlorophenyl)-19-methyl-(2R,10R)-11-oxa-8,19-diazahexacyclo[10.9.1.01,10.02,18.04,9.016,22]docosa-4(9),5,7,12,14,16(22)-hexaen-13-ol

SMILES CN1CC[C@@]23[C@H]4Oc5c2c(CC1[C@@H]3Cc1cc(cnc41)-c1ccc(Cl)cc1)ccc5O

InChI Key InChIKey=PFCJBVJVJPUGBT-UHFFFAOYSA-N

Data  5 KI  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50140901   

TargetMu-type opioid receptor(Guinea pig)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50140901(6-(4-chlorophenyl)-19-methyl-(2R,10R)-11-oxa-8,19-...)
Affinity DataEC50:  900nMAssay Description:Agonistic activity towards Opioid receptor mu 1 was determined in [35S]GTP-gamma-S, binding assay in guinea pig caudate; g = not active as an agonistMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50140901(6-(4-chlorophenyl)-19-methyl-(2R,10R)-11-oxa-8,19-...)
Affinity DataIC50: 177nMAssay Description:Inhibitory concentration for inhibition of Opioid receptor mu 1 induced contractions in guinea pig ileum (GPI) smooth muscle assaysMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Mouse)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50140901(6-(4-chlorophenyl)-19-methyl-(2R,10R)-11-oxa-8,19-...)
Affinity DataIC50: 565nMAssay Description:Inhibitory concentration required for 50 percent inhibition of opioid receptor delta 1 induced contractions in mouse vas deferens (MVD) smooth muscle...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Rat)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50140901(6-(4-chlorophenyl)-19-methyl-(2R,10R)-11-oxa-8,19-...)
Affinity DataKi:  4.40nMAssay Description:Binding affinity at opioid receptor delta 1 by displacement of [3H]DADLE in rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50140901(6-(4-chlorophenyl)-19-methyl-(2R,10R)-11-oxa-8,19-...)
Affinity DataKi:  11nMAssay Description:Apparent antagonist activity determined by measuring the ability to inhibit stimulation of [35S]GTP-gamma-S, binding to opioid receptor delta 1 in gu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50140901(6-(4-chlorophenyl)-19-methyl-(2R,10R)-11-oxa-8,19-...)
Affinity DataKi:  78nMAssay Description:Binding affinity at Opioid receptor kappa 1 by displacement of [3H]U-69593 in guinea pig brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Rat)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50140901(6-(4-chlorophenyl)-19-methyl-(2R,10R)-11-oxa-8,19-...)
Affinity DataKi:  148nMAssay Description:Binding affinity at Opioid receptor mu 1 by displacement of [3H]DAMGO in rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50140901(6-(4-chlorophenyl)-19-methyl-(2R,10R)-11-oxa-8,19-...)
Affinity DataKi:  333nMAssay Description:Apparent binding affinity of compound was determined by antagonism towards Opioid receptor kappa 1 in [35S]GTP-gamma-S, binding assay in guinea pig c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed