BDBM50140860 4-{4-[2-(3,4-Difluoro-phenyl)-ethyl]-piperazin-1-yl}-8-(pyrrolidine-1-sulfonyl)-5H-pyrimido[5,4-b]indole::CHEMBL27128

SMILES Fc1ccc(CCN2CCN(CC2)c2ncnc3c4cc(ccc4[nH]c23)S(=O)(=O)N2CCCC2)cc1F

InChI Key InChIKey=YYLHEIDJNAZEPK-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50140860   

LigandPNGBDBM50140860(4-{4-[2-(3,4-Difluoro-phenyl)-ethyl]-piperazin-1-y...)
Affinity DataIC50: 235nMAssay Description:In vitro inhibitory activity against MRP1 (Multidrug resistance associated protein 1) expressed in COR.L23/R cell line in accumulation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50140860(4-{4-[2-(3,4-Difluoro-phenyl)-ethyl]-piperazin-1-y...)
Affinity DataIC50: 542nMAssay Description:Inhibitory activity against MRP1 (Multidrug resistance associated protein 1) expressed in COR.L23/R cell line in single-dose potentiation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50140860(4-{4-[2-(3,4-Difluoro-phenyl)-ethyl]-piperazin-1-y...)
Affinity DataIC50: 250nMAssay Description:Inhibitory concentration against multidrug resistance associated protein 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Mouse)
Xenova

Curated by ChEMBL
LigandPNGBDBM50140860(4-{4-[2-(3,4-Difluoro-phenyl)-ethyl]-piperazin-1-y...)
Affinity DataIC50: 3.31E+3nMAssay Description:In vitro inhibitory activity against P-glycoprotein expressed in murine mammary carcinoma (EMT6/AR1.0 cell line) in accumulation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50140860(4-{4-[2-(3,4-Difluoro-phenyl)-ethyl]-piperazin-1-y...)
Affinity DataIC50: 235nMAssay Description:Inhibition of MRP1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetATP-dependent translocase ABCB1(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50140860(4-{4-[2-(3,4-Difluoro-phenyl)-ethyl]-piperazin-1-y...)
Affinity DataIC50: 3.31E+3nMAssay Description:Inhibition of P-gp (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed