BDBM50140833 4-(4-Chloro-benzylsulfanyl)-6,7,8,9-tetrahydro-5H-1,3,4b-triaza-benzo[a]azulene-10-carbonitrile::CHEMBL281938

SMILES Clc1ccc(CSc2ncnc3c(C#N)c4CCCCCn4c23)cc1

InChI Key InChIKey=UARYNWRIVAFKLK-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50140833   

LigandPNGBDBM50140833(4-(4-Chloro-benzylsulfanyl)-6,7,8,9-tetrahydro-5H-...)
Affinity DataIC50: 3.90E+3nMAssay Description:Inhibitory activity against human transporter MRP1 (Multidrug resistance associated protein 1) expressed in COR.L23/R cell lineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50140833(4-(4-Chloro-benzylsulfanyl)-6,7,8,9-tetrahydro-5H-...)
Affinity DataIC50: 3.90E+3nMAssay Description:Inhibition of MRP1 in human COR-L23/R cells assessed reduction in tritiated daunomycin efflux incubated for 2 hrs by radioactivity based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed