BDBM50140832 4-Phenethylamino-6,7,8,9-tetrahydro-pyrimido[4,5-b]indolizine-10-carbonitrile::CHEMBL282611

SMILES N#Cc1c2CCCCn2c2c(NCCc3ccccc3)ncnc12

InChI Key InChIKey=DVCJSKQKVMMANY-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50140832   

LigandPNGBDBM50140832(4-Phenethylamino-6,7,8,9-tetrahydro-pyrimido[4,5-b...)
Affinity DataIC50: 6.30E+3nMAssay Description:Inhibitory activity against human transporter MRP1 (Multidrug resistance associated protein 1) expressed in COR.L23/R cell lineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Mouse)
Xenova

Curated by ChEMBL
LigandPNGBDBM50140832(4-Phenethylamino-6,7,8,9-tetrahydro-pyrimido[4,5-b...)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibitory activity against mouse transporter Pgp (P-glycoprotein) expressed in EMT6/AR1.0 cell lineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50140832(4-Phenethylamino-6,7,8,9-tetrahydro-pyrimido[4,5-b...)
Affinity DataIC50: 4.98E+3nMAssay Description:Inhibition of MRP1 in human H69AR cells assessed as daunorubicin accumulation preincubated for 15 mins measured after 180 mins by flow cytometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2017
Entry Details Article
PubMed
LigandPNGBDBM50140832(4-Phenethylamino-6,7,8,9-tetrahydro-pyrimido[4,5-b...)
Affinity DataIC50: 8.37E+3nMAssay Description:Inhibition of MRP1 in human H69AR cells incubated for 20 mins measured every 60 mins by calcein-AM accumulation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2017
Entry Details Article
PubMed