BDBM50140831 4-{4-[2-(4-Nitro-phenyl)-ethyl]-piperazin-1-yl}-6,7,8,9-tetrahydro-pyrimido[4,5-b]indolizine-10-carbonitrile::CHEMBL27171

SMILES [O-][N+](=O)c1ccc(CCN2CCN(CC2)c2ncnc3c(C#N)c4CCCCn4c23)cc1

InChI Key InChIKey=NWDZIFVRECEPHK-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50140831   

LigandPNGBDBM50140831(4-{4-[2-(4-Nitro-phenyl)-ethyl]-piperazin-1-yl}-6,...)
Affinity DataIC50: 523nMAssay Description:Inhibitory activity against human transporter MRP1 (Multidrug resistance associated protein 1) expressed in COR.L23/R cell lineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Mouse)
Xenova

Curated by ChEMBL
LigandPNGBDBM50140831(4-{4-[2-(4-Nitro-phenyl)-ethyl]-piperazin-1-yl}-6,...)
Affinity DataIC50: 1.29E+4nMAssay Description:Inhibitory activity against mouse transporter Pgp (P-glycoprotein) expressed in EMT6/AR1.0 cell lineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed