BDBM50140824 4-(4-Phenylmethanesulfonyl-piperazin-1-yl)-6,7,8,9-tetrahydro-pyrimido[4,5-b]indolizine-10-carbonitrile::CHEMBL285830

SMILES O=S(=O)(Cc1ccccc1)N1CCN(CC1)c1ncnc2c(C#N)c3CCCCn3c12

InChI Key InChIKey=IOSFUQKPGNNSCC-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50140824   

LigandPNGBDBM50140824(4-(4-Phenylmethanesulfonyl-piperazin-1-yl)-6,7,8,9...)
Affinity DataIC50: 6.65E+3nMAssay Description:Inhibitory activity against human transporter MRP1 (Multidrug resistance associated protein 1) expressed in COR.L23/R cell lineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Mouse)
Xenova

Curated by ChEMBL
LigandPNGBDBM50140824(4-(4-Phenylmethanesulfonyl-piperazin-1-yl)-6,7,8,9...)
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibitory activity against mouse transporter Pgp (P-glycoprotein) expressed in EMT6/AR1.0 cell lineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed