BDBM50140821 4-{4-[2-(1H-Indol-3-yl)-ethyl]-piperazin-1-yl}-6,7,8,9-tetrahydro-pyrimido[4,5-b]indolizine-10-carbonitrile::CHEMBL27861

SMILES N#Cc1c2CCCCn2c2c(ncnc12)N1CCN(CCc2c[nH]c3ccccc23)CC1

InChI Key InChIKey=FMKRSOMSQRDCJI-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50140821   

LigandPNGBDBM50140821(4-{4-[2-(1H-Indol-3-yl)-ethyl]-piperazin-1-yl}-6,7...)
Affinity DataIC50: 600nMAssay Description:Inhibitory activity against human transporter MRP1 (Multidrug resistance associated protein 1) expressed in COR.L23/R cell lineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Mouse)
Xenova

Curated by ChEMBL
LigandPNGBDBM50140821(4-{4-[2-(1H-Indol-3-yl)-ethyl]-piperazin-1-yl}-6,7...)
Affinity DataIC50: 5.82E+3nMAssay Description:Inhibitory activity against mouse transporter Pgp (P-glycoprotein) expressed in EMT6/AR1.0 cell lineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50140821(4-{4-[2-(1H-Indol-3-yl)-ethyl]-piperazin-1-yl}-6,7...)
Affinity DataIC50: 3.41E+3nMAssay Description:Inhibition of BCRP (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetATP-dependent translocase ABCB1(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50140821(4-{4-[2-(1H-Indol-3-yl)-ethyl]-piperazin-1-yl}-6,7...)
Affinity DataIC50: 5.62E+3nMAssay Description:Inhibition of P-gp (unknown origin) incubated for 30 mins by calcein AM analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
LigandPNGBDBM50140821(4-{4-[2-(1H-Indol-3-yl)-ethyl]-piperazin-1-yl}-6,7...)
Affinity DataIC50: 344nMAssay Description:Inhibition of MRP1 in human NCI-H69AR cells incubated for 180 mins in presence of daunorubicin by flow cytometry analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
LigandPNGBDBM50140821(4-{4-[2-(1H-Indol-3-yl)-ethyl]-piperazin-1-yl}-6,7...)
Affinity DataIC50: 3.41E+3nMAssay Description:Inhibition of BCRP (unknown origin) expressed in dog MDCK-II cells using pheophorbide A as substrate preincubated for 20 mins followed by substrate a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed