BDBM50140098 1-(2,6-Difluoro-benzyl)-5-(2-fluoro-3-methoxy-phenyl)-6-methyl-3-{(S)-2-[(3-methyl-thiophen-2-ylmethyl)-amino]-propyl}-1H-pyrimidine-2,4-dione::CHEMBL283381

SMILES COc1cccc(c1F)-c1c(C)n(Cc2c(F)cccc2F)c(=O)n(C[C@H](C)NCc2sccc2C)c1=O

InChI Key InChIKey=UOSJSHOYCNDHMM-UHFFFAOYSA-N

Data  3 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50140098   

TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50140098(1-(2,6-Difluoro-benzyl)-5-(2-fluoro-3-methoxy-phen...)
Affinity DataIC50: 4nMAssay Description:In vitro inhibition of [Ca2+] influx in RBL cells expressing Gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50140098(1-(2,6-Difluoro-benzyl)-5-(2-fluoro-3-methoxy-phen...)
Affinity DataKi:  4nMAssay Description:Binding affinity evaluated by the ability to inhibit des-Gly10[125I]Tyr5,D-Leu6,NMeLeu7,Pro9-NEt]- Gonadotropin-releasing hormone binding to cloned h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50140098(1-(2,6-Difluoro-benzyl)-5-(2-fluoro-3-methoxy-phen...)
Affinity DataKi:  87nMAssay Description:In vivo inhibition of monkey Gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Rat)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50140098(1-(2,6-Difluoro-benzyl)-5-(2-fluoro-3-methoxy-phen...)
Affinity DataKi:  3.20E+3nMAssay Description:In vivo inhibition of rat Gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed