BDBM50139192 4-(3,3-dimethyl-1-butynyl)-23-oxo-8-oxa-1,15,17,21-tetraazapentacyclo[19.2.2.13,7.19,13.015,19]heptacosa-3(27),4,6,9(26),10,12,16,18-octaen-10-yl cyanide::CHEMBL346589

SMILES CC(C)(C)C#Cc1ccc2Oc3cc(Cn4cncc4CN4CCN(Cc1c2)C(=O)C4)ccc3C#N

InChI Key InChIKey=IZYCQMKDUPSJSI-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50139192   

LigandPNGBDBM50139192(4-(3,3-dimethyl-1-butynyl)-23-oxo-8-oxa-1,15,17,21...)
Affinity DataIC50: 55nMAssay Description:Inhibition of human Geranylgeranyl transferase type I incorporation of [3H]GGPP into biotinylated peptide corresponding to the C-terminus of human Ki...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50139192(4-(3,3-dimethyl-1-butynyl)-23-oxo-8-oxa-1,15,17,21...)
Affinity DataIC50: 38nMAssay Description:Inhibition of human Farnesyltransferase -catalyzed incorporation of [3H]FPP into recombinant Ras-CVIM.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50139192(4-(3,3-dimethyl-1-butynyl)-23-oxo-8-oxa-1,15,17,21...)
Affinity DataIC50: 10nMAssay Description:Displacement of radiolabeled FTI from Farnesyltransferase in cultured Ha-ras transformed RAT1 cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed