BDBM50138883 6-Butyl-N*2*,N*4*-dipropyl-pyrimidine-2,4-diamine::6-butyl-2,4-dipropylaminopyrimidine::CHEMBL352024

SMILES CCCCc1cc(NCCC)nc(NCCC)n1

InChI Key InChIKey=UYWCDBMUBBSZOJ-UHFFFAOYSA-N

Data  5 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50138883   

TargetEstrogen receptor(Human)
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50138883(6-butyl-2,4-dipropylaminopyrimidine | 6-Butyl-N*2*...)
Affinity DataIC50: 1.30E+4nMAssay Description:Antagonist activity at ERalpha in human HEC1 cells assessed as inhibition of estrogen-induced transcriptional activity after 24 hrs by reporter gene ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50138883(6-butyl-2,4-dipropylaminopyrimidine | 6-Butyl-N*2*...)
Affinity DataKi:  1.60E+4nMAssay Description:Binding affinity to ERalpha assessed as inhibition of fluorescein-labeled nuclear receptor domain of steroid receptor coactivator 3 by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetEstrogen receptor beta(Human)
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50138883(6-butyl-2,4-dipropylaminopyrimidine | 6-Butyl-N*2*...)
Affinity DataKi:  1.60E+4nMAssay Description:Binding affinity to ERbeta assessed as inhibition of steroid receptor coactivator 2 interaction by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50138883(6-butyl-2,4-dipropylaminopyrimidine | 6-Butyl-N*2*...)
Affinity DataKi:  3.20E+4nMAssay Description:Binding affinity to ERalpha assessed as inhibition of steroid receptor coactivator 2 interaction by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetEstrogen receptor beta(Human)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM50138883(6-butyl-2,4-dipropylaminopyrimidine | 6-Butyl-N*2*...)
Affinity DataKi:  3.20E+4nMAssay Description:Binding affinity towards estrogen receptor was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetEstrogen receptor beta(Human)
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50138883(6-butyl-2,4-dipropylaminopyrimidine | 6-Butyl-N*2*...)
Affinity DataKi: >1.00E+6nMAssay Description:Binding affinity to ERbeta assessed as inhibition of fluorescein-labeled nuclear receptor domain of steroid receptor coactivator 3 by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed