BDBM50138643 2-[3-(4-Fluoro-phenyl)-isoxazol-5-yl]-8-methyl-3-p-tolyl-8-aza-bicyclo[3.2.1]octane::CHEMBL102279

SMILES CN1C2CCC1C(C(C2)c1ccc(C)cc1)c1cc(no1)-c1ccc(F)cc1

InChI Key InChIKey=HDJDHOXJDMHXTD-UHFFFAOYSA-N

Data  1 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50138643   

TargetSodium-dependent serotonin transporter(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50138643(2-[3-(4-Fluoro-phenyl)-isoxazol-5-yl]-8-methyl-3-p...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibitory concentration required to inhibit serotonin transporter 5-HTT was determined by using [3H]paroxetine radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50138643(2-[3-(4-Fluoro-phenyl)-isoxazol-5-yl]-8-methyl-3-p...)
Affinity DataIC50: 6.45nMAssay Description:Inhibitory concentration required to inhibit dopamine transporter DAT was determined by using [3H]WIN-35428 radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetTransporter(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50138643(2-[3-(4-Fluoro-phenyl)-isoxazol-5-yl]-8-methyl-3-p...)
Affinity DataIC50: 917nMAssay Description:Inhibition of norepinephrine transporter (NET) determined using [3H]nisoxetine radioligand.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetTransporter(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50138643(2-[3-(4-Fluoro-phenyl)-isoxazol-5-yl]-8-methyl-3-p...)
Affinity DataKi:  552nMAssay Description:Binding affinity towards norepinephrine transporter was determined using [3H]nisoxetine radioligand.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed