BDBM50138642 3-(4-Chloro-phenyl)-2-isoxazol-5-yl-8-methyl-8-aza-bicyclo[3.2.1]octane::CHEMBL103523

SMILES CN1C2CCC1C(C(C2)c1ccc(Cl)cc1)c1ccno1

InChI Key InChIKey=OOCVKMWYXDRARP-UHFFFAOYSA-N

Data  2 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50138642   

TargetTransporter(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50138642(3-(4-Chloro-phenyl)-2-isoxazol-5-yl-8-methyl-8-aza...)
Affinity DataIC50: 87nMAssay Description:Inhibition of norepinephrine transporter (NET) determined using [3H]nisoxetine radioligand.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50138642(3-(4-Chloro-phenyl)-2-isoxazol-5-yl-8-methyl-8-aza...)
Affinity DataIC50: 0.770nMAssay Description:Inhibitory concentration required to inhibit dopamine transporter DAT was determined by using [3H]WIN-35428 radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50138642(3-(4-Chloro-phenyl)-2-isoxazol-5-yl-8-methyl-8-aza...)
Affinity DataIC50: 91nMAssay Description:Inhibitory concentration required to inhibit serotonin transporter 5-HTT was determined by using [3H]paroxetine radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50138642(3-(4-Chloro-phenyl)-2-isoxazol-5-yl-8-methyl-8-aza...)
Affinity DataKi:  8.20nMAssay Description:Binding affinity towards serotonin transporter 5-HTT was determined using [3H]paroxetine radioligand.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetTransporter(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50138642(3-(4-Chloro-phenyl)-2-isoxazol-5-yl-8-methyl-8-aza...)
Affinity DataKi:  52nMAssay Description:Binding affinity towards norepinephrine transporter was determined using [3H]nisoxetine radioligand.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed