BDBM50138465 CHEMBL3752684

SMILES NC1=NC(NC(=O)N1)c1ccc(F)cc1

InChI Key InChIKey=IIPYBCQHBOPOGK-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50138465   

TargetBeta-secretase 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50138465(CHEMBL3752684)
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of BACE-1 (unknown origin) using M-2420 as substrate preincubated for 1 hr followed by substrate addition measured after 15 mins by FRET a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2017
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50138465(CHEMBL3752684)
Affinity DataIC50: 1.47E+4nMAssay Description:Inhibition of recombinant human GSK3beta using prephosphorylated polypeptide as substrate preincubated for 30 mins followed by addition of kinase-glo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50138465(CHEMBL3752684)
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of BACE-1 (unknown origin) using peptide mimicking APP sequence as substrate preincubated for 1 hr followed by substrate addition measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50138465(CHEMBL3752684)
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of BACE-1 (unknown origin) using methoxycoumarin-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Lysdinitrophenyl as substrate preincubated for 1 hr f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50138465(CHEMBL3752684)
Affinity DataIC50: 1.47E+4nMAssay Description:Inhibition of recombinant human GSK-3beta using prephosphorylated polypeptide substrate measured after 30 mins in presence of ATP by Kinase-Glo Lumin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed