BDBM50137615 5-Bromo-N-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-ethyl]-2,3-dimethoxy-benzamide::CHEMBL64176

SMILES COc1cc2CCN(CCNC(=O)c3cc(Br)cc(OC)c3OC)Cc2cc1OC

InChI Key InChIKey=GSHZYENJHIPEJJ-UHFFFAOYSA-N

Data  5 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50137615   

TargetD(3) dopamine receptor(Rat)
Wake Forest University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50137615(5-Bromo-N-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquin...)
Affinity DataKi:  21nMAssay Description:Binding affinity at dopamine receptor D3 on Sf9 cells by [125I]IABN displacement.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
Wake Forest University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50137615(5-Bromo-N-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquin...)
Affinity DataKi:  265nMAssay Description:Binding affinity for human dopamine receptor D4 using [125I]IABN as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
Wake Forest University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50137615(5-Bromo-N-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquin...)
Affinity DataKi:  714nMAssay Description:Binding affinity at dopamine receptor D2 on Sf9 cells by [125I]IABN displacement.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50137615(5-Bromo-N-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquin...)
Affinity DataKi:  2.93E+3nMAssay Description:Binding affinity to sigma-1 opioid receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50137615(5-Bromo-N-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquin...)
Affinity DataKi:  2.93E+3nMAssay Description:Inhibition of [3H](+)-pentazocine binding to Sigma opioid receptor of guiena pig brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed