BDBM50137397 CHEMBL341014::[(S)-1-((S)-1-Benzyl-2-oxo-ethylcarbamoyl)-3-methyl-butyl]-carbamic acid benzyl ester

SMILES CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C=O

InChI Key InChIKey=CSKGFHNQMOIAFM-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50137397   

TargetCalpain-1 catalytic subunit(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50137397([(S)-1-((S)-1-Benzyl-2-oxo-ethylcarbamoyl)-3-methy...)
Affinity DataIC50: 10nMAssay Description:Inhibitory activity was evaluated against recombinant human calpain IMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2010
Entry Details Article

LigandPNGBDBM50137397([(S)-1-((S)-1-Benzyl-2-oxo-ethylcarbamoyl)-3-methy...)
Affinity DataIC50: 35nMAssay Description:Inhibition of Calpain 1 by [3H]acetyl-casein assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

TargetProcathepsin L(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50137397([(S)-1-((S)-1-Benzyl-2-oxo-ethylcarbamoyl)-3-methy...)
Affinity DataKi:  20nMAssay Description:Inhibitory activity against recombinant human cathepsin L (1.2 nM)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed