BDBM50137278 2-(2,5-Dichloro-benzenesulfonyl)-6-hydroxy-1,2,3,4-tetrahydro-isoquinoline-1-carboxylic acid hydroxyamide::2-(2,5-dichlorophenylsulfonyl)-N,6-dihydroxy-1,2,3,4-tetrahydroisoquinoline-1-carboxamide::CHEMBL424130

SMILES ONC(=O)C1N(CCc2cc(O)ccc12)S(=O)(=O)c1cc(Cl)ccc1Cl

InChI Key InChIKey=QMIAXILIKVOPKK-UHFFFAOYSA-N

Data  18 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50137278   

TargetInterstitial collagenase(Human)
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM50137278(2-(2,5-Dichloro-benzenesulfonyl)-6-hydroxy-1,2,3,4...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of MMP-1 (unknown origin) expressed in Escherichia coli BL21(DE3) and measured for 2 mins by enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetMatrix metalloproteinase-26(Human)
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM50137278(2-(2,5-Dichloro-benzenesulfonyl)-6-hydroxy-1,2,3,4...)
Affinity DataIC50: 7.90E+3nMAssay Description:Inhibition of MMP-26 (unknown origin) expressed in Escherichia coli BL21(DE3) and measured for 2 mins by enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetMatrix metalloproteinase-16(Human)
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM50137278(2-(2,5-Dichloro-benzenesulfonyl)-6-hydroxy-1,2,3,4...)
Affinity DataIC50: 1.84E+3nMAssay Description:Inhibition of MMP-16 (unknown origin) expressed in Escherichia coli BL21(DE3) and measured for 2 mins by enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetMatrix metalloproteinase-15(Human)
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM50137278(2-(2,5-Dichloro-benzenesulfonyl)-6-hydroxy-1,2,3,4...)
Affinity DataIC50: 1.79E+3nMAssay Description:Inhibition of MMP-15 (unknown origin) expressed in Escherichia coli BL21(DE3) and measured for 2 mins by enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetMatrix metalloproteinase-14(Human)
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM50137278(2-(2,5-Dichloro-benzenesulfonyl)-6-hydroxy-1,2,3,4...)
Affinity DataIC50: 4.61E+3nMAssay Description:Inhibition of MMP-14 (unknown origin) expressed in Escherichia coli BL21(DE3) and measured for 2 mins by enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetMacrophage metalloelastase(Human)
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM50137278(2-(2,5-Dichloro-benzenesulfonyl)-6-hydroxy-1,2,3,4...)
Affinity DataIC50: 170nMAssay Description:Inhibition of MMP-12 (unknown origin) expressed in Escherichia coli BL21(DE3) and measured for 2 mins by enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetMatrix metalloproteinase-9(Human)
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM50137278(2-(2,5-Dichloro-benzenesulfonyl)-6-hydroxy-1,2,3,4...)
Affinity DataIC50: 1.88E+3nMAssay Description:Inhibition of MMP-9 (unknown origin) expressed in Escherichia coli BL21(DE3) and measured for 2 mins by enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetMatrilysin(Human)
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM50137278(2-(2,5-Dichloro-benzenesulfonyl)-6-hydroxy-1,2,3,4...)
Affinity DataIC50: 2.14E+4nMAssay Description:Inhibition of MMP-7 (unknown origin) expressed in Escherichia coli BL21(DE3) and measured for 2 mins by enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
Target72 kDa type IV collagenase(Human)
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM50137278(2-(2,5-Dichloro-benzenesulfonyl)-6-hydroxy-1,2,3,4...)
Affinity DataIC50: 853nMAssay Description:Inhibition of MMP-2 (unknown origin) expressed in Escherichia coli BL21(DE3) and measured for 2 mins by enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetMatrix metalloproteinase-9(Human)
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM50137278(2-(2,5-Dichloro-benzenesulfonyl)-6-hydroxy-1,2,3,4...)
Affinity DataIC50: 1.88E+3nMAssay Description:Inhibition of matrix metalloprotease-9 (MMP-9)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMatrilysin(Human)
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM50137278(2-(2,5-Dichloro-benzenesulfonyl)-6-hydroxy-1,2,3,4...)
Affinity DataIC50: 2.14E+4nMAssay Description:Inhibition of MMP7More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM50137278(2-(2,5-Dichloro-benzenesulfonyl)-6-hydroxy-1,2,3,4...)
Affinity DataIC50: 853nMAssay Description:Inhibition of matrix metalloprotease-2 (MMP-2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMatrix metalloproteinase-16(Human)
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM50137278(2-(2,5-Dichloro-benzenesulfonyl)-6-hydroxy-1,2,3,4...)
Affinity DataIC50: 1.84E+3nMAssay Description:Inhibition of matrix metalloprotease-16 (MMP-16)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMatrix metalloproteinase-26(Human)
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM50137278(2-(2,5-Dichloro-benzenesulfonyl)-6-hydroxy-1,2,3,4...)
Affinity DataIC50: 7.90E+3nMAssay Description:Inhibition of matrix metalloprotease-26 (MMP-26)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMatrilysin(Human)
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM50137278(2-(2,5-Dichloro-benzenesulfonyl)-6-hydroxy-1,2,3,4...)
Affinity DataIC50: 2.14E+4nMAssay Description:Inhibition of matrix metalloprotease-7 (MMP-7)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMatrix metalloproteinase-15(Human)
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM50137278(2-(2,5-Dichloro-benzenesulfonyl)-6-hydroxy-1,2,3,4...)
Affinity DataIC50: 1.79E+3nMAssay Description:Inhibition of matrix metalloprotease-15 (MMP-15)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM50137278(2-(2,5-Dichloro-benzenesulfonyl)-6-hydroxy-1,2,3,4...)
Affinity DataIC50: 170nMAssay Description:Inhibition of matrix metalloprotease-12 (MMP-12)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMatrix metalloproteinase-14(Human)
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM50137278(2-(2,5-Dichloro-benzenesulfonyl)-6-hydroxy-1,2,3,4...)
Affinity DataIC50: 4.61E+3nMAssay Description:Inhibition of matrix metalloprotease-14 (MMP-14)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed