BDBM50136273 (3R,4S)-1-Thiazol-2-ylmethyl-piperidine-3,4-dicarboxylic acid 4-hydroxyamide 3-{[4-(2-methyl-quinolin-4-ylmethoxy)-phenyl]-amide}::CHEMBL134782

SMILES Cc1cc(COc2ccc(NC(=O)[C@H]3CN(Cc4nccs4)CC[C@@H]3C(=O)NO)cc2)c2ccccc2n1

InChI Key InChIKey=WKVGPQBRJBFDSN-UHFFFAOYSA-N

Data  3 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50136273   

TargetDisintegrin and metalloproteinase domain-containing protein 17(Pig)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50136273((3R,4S)-1-Thiazol-2-ylmethyl-piperidine-3,4-dicarb...)
Affinity DataIC50: 0.800nMAssay Description:In vitro binding affinity against porcine TACEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50136273((3R,4S)-1-Thiazol-2-ylmethyl-piperidine-3,4-dicarb...)
Affinity DataKi: >2.13E+3nMAssay Description:Inhibitory activity against matrix metalloprotease-9 (MMP-9)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50136273((3R,4S)-1-Thiazol-2-ylmethyl-piperidine-3,4-dicarb...)
Affinity DataKi: >3.33E+3nMAssay Description:Inhibitory activity against matrix metalloprotease-2 (MMP-2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50136273((3R,4S)-1-Thiazol-2-ylmethyl-piperidine-3,4-dicarb...)
Affinity DataKi: >4.95E+3nMAssay Description:Inhibitory activity against matrix metalloprotease-1 (MMP-1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed