BDBM50135668 3-(4-Benzyl-piperazin-1-ylmethyl)-pyrimido[5,4-e][1,2,4]triazine-5,7-diamine::CHEMBL96952

SMILES Nc1nc(N)c2nc(CN3CCN(Cc4ccccc4)CC3)nnc2n1

InChI Key InChIKey=IDGWYMMARYUEBB-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50135668   

TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50135668(3-(4-Benzyl-piperazin-1-ylmethyl)-pyrimido[5,4-e][...)
Affinity DataIC50: 6.20E+3nMAssay Description:Inhibition of Protein-tyrosine phosphatase 1B in 300 nM DTTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein phosphatase F(Human)
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50135668(3-(4-Benzyl-piperazin-1-ylmethyl)-pyrimido[5,4-e][...)
Affinity DataIC50: 1.20E+4nMAssay Description:In vitro inhibitory concentration required against Leukocyte antigen related receptor phosphatase (LAR) in the presence of 300 nM DTTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50135668(3-(4-Benzyl-piperazin-1-ylmethyl)-pyrimido[5,4-e][...)
Affinity DataIC50: 9.00E+3nMAssay Description:In vitro inhibitory concentration required against Tyrosine phosphatase SHP-2 in the presence of 300 nM DTTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein phosphatase alpha(Human)
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50135668(3-(4-Benzyl-piperazin-1-ylmethyl)-pyrimido[5,4-e][...)
Affinity DataIC50: 2.40E+4nMAssay Description:In vitro inhibitory concentration required against Protein-tyrosine phosphatase alpha in the presence of 300 nM DTTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50135668(3-(4-Benzyl-piperazin-1-ylmethyl)-pyrimido[5,4-e][...)
Affinity DataIC50: 9.80E+4nMAssay Description:Inhibition of Protein-tyrosine phosphatase 1B in 2 mM DTTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50135668(3-(4-Benzyl-piperazin-1-ylmethyl)-pyrimido[5,4-e][...)
Affinity DataIC50: 6.20E+3nMAssay Description:Inhibition of Protein-tyrosine phosphatase 1B in 300 nM DTTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed