BDBM50135168 3,4,5-Trihydroxy-benzoic acid (2R,3S)-5,7-dihydroxy-2-(3,4,5-trihydroxy-phenyl)-chroman-3-yl ester::CHEMBL126079::US20240336588, Compound 5

SMILES Oc1cc(O)c2C[C@H](OC(=O)c3cc(O)c(O)c(O)c3)[C@H](Oc2c1)c1cc(O)c(O)c(O)c1

InChI Key InChIKey=WMBWREPUVVBILR-UHFFFAOYSA-N

Data  1 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50135168   

TargetBeta-secretase 1(Human)
Kyungpook National University

Curated by ChEMBL
LigandPNGBDBM50135168(3,4,5-Trihydroxy-benzoic acid (2R,3S)-5,7-dihydrox...)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of human Beta-secretase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50135168(3,4,5-Trihydroxy-benzoic acid (2R,3S)-5,7-dihydrox...)
Affinity DataIC50: 150nMAssay Description:Inhibition of DYRK1A (unknown origin) using HT-497 as substrate preincubated with compound followed by substrate addition and measured after 30 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
LigandPNGBDBM50135168(3,4,5-Trihydroxy-benzoic acid (2R,3S)-5,7-dihydrox...)
Affinity DataIC50: 100nMAssay Description:DYRK1A assay. Substrate, HT-PRD (Proline rich domain, residues 746-864 of dynamin 1a, prepared as N-terminal tagged 6×His fusion protein), was dilute...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2025
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Kyungpook National University

Curated by ChEMBL
LigandPNGBDBM50135168(3,4,5-Trihydroxy-benzoic acid (2R,3S)-5,7-dihydrox...)
Affinity DataKi:  170nMAssay Description:Inhibitory activity against recombinant human Beta-secretase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed