BDBM50134705 5-{2-[4-(2-Biphenyl-2-yl-2-hydroxy-acetylamino)-5-(3,5-difluoro-phenyl)-3-hydroxy-pentanoylamino]-3-methyl-butyrylamino}-isophthalic acid dimethyl ester::CHEMBL143687

SMILES COC(=O)c1cc(NC(=O)[C@@H](NC(=O)C[C@H](O)[C@H](Cc2cc(F)cc(F)c2)NC(=O)C(O)c2ccccc2-c2ccccc2)C(C)C)cc(c1)C(=O)OC

InChI Key InChIKey=JRFGPYJALXEIOO-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50134705   

TargetBeta-secretase 1(Human)
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50134705(5-{2-[4-(2-Biphenyl-2-yl-2-hydroxy-acetylamino)-5-...)
Affinity DataIC50: 120nMAssay Description:Compound was tested for its inhibitory activity against human beta-Secretase (BACE)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50134705(5-{2-[4-(2-Biphenyl-2-yl-2-hydroxy-acetylamino)-5-...)
Affinity DataEC50:  4.00E+3nMAssay Description:Compound was tested for its effective concentration against human beta-Secretase (BACE)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed