BDBM50134675 CHEMBL3747573::US9637484, 22

SMILES OC(=O)C1(CCC1)Sc1ccnc2ccc(cc12)-c1ccccc1C(F)(F)F

InChI Key InChIKey=WLKGFFKVKMXGNB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50134675   

TargetSolute carrier family 22 member 12(Human)
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50134675(CHEMBL3747573 | US9637484, 22)
Affinity DataIC50: 115nMAssay Description:Inhibition of human URAT1 expressed in HEK293 cells assessed as [14C]uric acid uptake after 12 mins by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2017
Entry Details Article
PubMed
TargetSolute carrier family 22 member 12(Human)
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50134675(CHEMBL3747573 | US9637484, 22)
Affinity DataIC50: 115nMAssay Description:In vitro URAT1 assay can be used to identify compounds having potential activity for decreasing serum uric acid. In a suitable test, the vectors that...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2019
Entry Details
Go to US Patent