BDBM50134635 CHEMBL3746329::US9637484, 3

SMILES OC(=O)C1(CCC1)Sc1ccnc2ccc(Br)cc12

InChI Key InChIKey=QGBWIYLNOBYNDL-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50134635   

TargetSolute carrier family 22 member 12(Human)
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50134635(CHEMBL3746329 | US9637484, 3)
Affinity DataIC50: 34nMAssay Description:Inhibition of human URAT1 expressed in HEK293 cells assessed as [14C]uric acid uptake after 12 mins by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2017
Entry Details Article
PubMed
TargetSolute carrier family 22 member 12(Human)
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50134635(CHEMBL3746329 | US9637484, 3)
Affinity DataIC50: 19nMAssay Description:In vitro URAT1 assay can be used to identify compounds having potential activity for decreasing serum uric acid. In a suitable test, the vectors that...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2019
Entry Details
Go to US Patent

TargetSolute carrier family 22 member 12(Human)
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50134635(CHEMBL3746329 | US9637484, 3)
Affinity DataIC50: 33nMAssay Description:Inhibition of human URAT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2019
Entry Details Article
PubMed
TargetSolute carrier family 22 member 12(Human)
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50134635(CHEMBL3746329 | US9637484, 3)
Affinity DataIC50: 34nMAssay Description:Inhibition of URAT1 (unknown origin) assessed as decrease in uric acid levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed