BDBM50134471 (1H-Benzoimidazol-2-yl)-{3-[4-(3-diisobutylamino-propyl)-piperazin-1-yl]-propyl}-amine::CHEMBL419432

SMILES CC(C)CN(CCCN1CCN(CCCNc2nc3ccccc3[nH]2)CC1)CC(C)C

InChI Key InChIKey=KLKKWCPJBTXWOV-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50134471   

TargetHistidine-rich protein PFHRP-II(malaria parasite P. falciparum)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50134471((1H-Benzoimidazol-2-yl)-{3-[4-(3-diisobutylamino-p...)
Affinity DataIC50: 6.36E+4nMAssay Description:Inhibition of 1-monooleoyl glycerol (MOG) induced beta-hematin formationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50134471((1H-Benzoimidazol-2-yl)-{3-[4-(3-diisobutylamino-p...)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of BACE1 in human SH-SY5Y cells harboring wild type APP695 assessed as reduction in amyloid beta (1 to 42) level after 24 hrs by ELISA met...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50134471((1H-Benzoimidazol-2-yl)-{3-[4-(3-diisobutylamino-p...)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of BACE1 in human SH-SY5Y cells harboring wild type APP695 assessed as reduction in amyloid beta (1 to 40) level after 24 hrs by ELISA met...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed