BDBM50134232 (E)-N-Hydroxy-3-(4-{[2-(1H-indol-3-yl)-ethylamino]-methyl}-phenyl)-acrylamide::CHEMBL344227

SMILES ONC(=O)\C=C\c1ccc(CNCCc2c[nH]c3ccccc23)cc1

InChI Key InChIKey=ZLUZDKXBTNQWOL-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50134232   

TargetHistone deacetylase 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50134232((E)-N-Hydroxy-3-(4-{[2-(1H-indol-3-yl)-ethylamino]...)
Affinity DataIC50: 15nMAssay Description:Inhibition of HDAC1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2013
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50134232((E)-N-Hydroxy-3-(4-{[2-(1H-indol-3-yl)-ethylamino]...)
Affinity DataIC50: 2.75E+4nMAssay Description:Inhibition of human ERG by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2013
Entry Details Article
PubMed
TargetHistone deacetylase(Human)
Mazandaran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50134232((E)-N-Hydroxy-3-(4-{[2-(1H-indol-3-yl)-ethylamino]...)
Affinity DataIC50: 63nMAssay Description:Inhibition of human H1299 cells derived HDAC using biotin-labeled SGRGKGGKGLGKGGAKRHRKVLRD peracetylated with [3H]acetate at lysine residue as substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetHistone deacetylase(Human)
Mazandaran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50134232((E)-N-Hydroxy-3-(4-{[2-(1H-indol-3-yl)-ethylamino]...)
Affinity DataIC50: 63nMAssay Description:Inhibitory activity against histone deacetylase (HDAC) enzyme obtained from H1299 human lung carcinoma cell lysatesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed