BDBM50134030 9-[4-(N,N-dimethylamino)phenylamino]-3,6-bis(3-pyrrolodinopropionamido) acridine::CHEMBL336434::N,N'-(9-{[4-(dimethylamino)phenyl]amino}acridine-3,6-diyl)bis(3-pyrrolidin-1-ylpropanamide)

SMILES CN(C)c1ccc(cc1)Nc2c3ccc(cc3nc4c2ccc(c4)NC(=O)CCN5CCCC5)NC(=O)CCN6CCCC6

InChI Key InChIKey=RKPYSYRMIXRZJT-UHFFFAOYSA-N

Data  9 IC50  5 EC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50134030   

TargetTelomerase reverse transcriptase(Human)
University of London

Curated by ChEMBL
LigandPNGBDBM50134030(N,N'-(9-{[4-(dimethylamino)phenyl]amino}acridine-3...)
Affinity DataEC50:  115nMAssay Description:Inhibitory activity against human telomeraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTelomerase reverse transcriptase(Human)
University of London

Curated by ChEMBL
LigandPNGBDBM50134030(N,N'-(9-{[4-(dimethylamino)phenyl]amino}acridine-3...)
Affinity DataEC50:  113nMAssay Description:Effective concentration against telomerase by TRAPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTelomerase reverse transcriptase(Human)
University of London

Curated by ChEMBL
LigandPNGBDBM50134030(N,N'-(9-{[4-(dimethylamino)phenyl]amino}acridine-3...)
Affinity DataEC50:  113nMAssay Description:Inhibition of telomerase activity from human A2780 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTelomerase reverse transcriptase(Human)
University of London

Curated by ChEMBL
LigandPNGBDBM50134030(N,N'-(9-{[4-(dimethylamino)phenyl]amino}acridine-3...)
Affinity DataEC50:  6.30E+3nMAssay Description:Inhibition of telomerase by TRAP-LIG assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTelomerase reverse transcriptase(Human)
University of London

Curated by ChEMBL
LigandPNGBDBM50134030(N,N'-(9-{[4-(dimethylamino)phenyl]amino}acridine-3...)
Affinity DataIC50: 5.40E+3nMAssay Description:Inhibition of human telomerase assessed as unincorporated [alpha32P]dGTPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProtection of telomeres protein 1(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50134030(N,N'-(9-{[4-(dimethylamino)phenyl]amino}acridine-3...)
Affinity DataIC50: 6.30E+4nMAssay Description:Inhibition of human 35S-labeled Pot1 binding to human telomeric DNAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTelomerase reverse transcriptase(Human)
University of London

Curated by ChEMBL
LigandPNGBDBM50134030(N,N'-(9-{[4-(dimethylamino)phenyl]amino}acridine-3...)
Affinity DataIC50: 90nMAssay Description:Inhibition of human telomerase in A549 cells by TRAP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetTelomerase reverse transcriptase(Human)
University of London

Curated by ChEMBL
LigandPNGBDBM50134030(N,N'-(9-{[4-(dimethylamino)phenyl]amino}acridine-3...)
Affinity DataIC50: 100nMAssay Description:Inhibition of telomerase in human A2780 cells by TRAP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetTelomerase reverse transcriptase(Human)
University of London

Curated by ChEMBL
LigandPNGBDBM50134030(N,N'-(9-{[4-(dimethylamino)phenyl]amino}acridine-3...)
Affinity DataEC50:  120nMAssay Description:Inhibition of human telomerase by TRAP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetTelomerase reverse transcriptase(Human)
University of London

Curated by ChEMBL
LigandPNGBDBM50134030(N,N'-(9-{[4-(dimethylamino)phenyl]amino}acridine-3...)
Affinity DataIC50: 65nMAssay Description:Inhibition of human telomerase expressed in HEK293T cells treated after telomerase elongation by telomeric repeat amplification protocol assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetTelomerase reverse transcriptase(Human)
University of London

Curated by ChEMBL
LigandPNGBDBM50134030(N,N'-(9-{[4-(dimethylamino)phenyl]amino}acridine-3...)
Affinity DataIC50: 830nMAssay Description:Inhibition of human telomerase expressed in HEK293T cells in presence of primer (T2AG3)3 by primer extension assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetTelomerase reverse transcriptase(Human)
University of London

Curated by ChEMBL
LigandPNGBDBM50134030(N,N'-(9-{[4-(dimethylamino)phenyl]amino}acridine-3...)
Affinity DataIC50: 45nMAssay Description:Inhibition of human telomerase expressed in HEK293T cells treated before telomerase elongation by telomeric repeat amplification protocol assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetTelomerase reverse transcriptase(Human)
University of London

Curated by ChEMBL
LigandPNGBDBM50134030(N,N'-(9-{[4-(dimethylamino)phenyl]amino}acridine-3...)
Affinity DataIC50: 115nMAssay Description:Inhibition of human telomerase incubated for 20 mins by TRAP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetTelomerase reverse transcriptase(Human)
University of London

Curated by ChEMBL
LigandPNGBDBM50134030(N,N'-(9-{[4-(dimethylamino)phenyl]amino}acridine-3...)
Affinity DataIC50: 95nMAssay Description:Inhibition of telomerase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed