BDBM50133824 4-(3-Cyano-pyridin-2-yl)-piperazine-1-carboxylic acid (4-isopropyl-phenyl)-amide::CHEMBL121092

SMILES CC(C)c1ccc(NC(=O)N2CCN(CC2)c2ncccc2C#N)cc1

InChI Key InChIKey=HEIOPGPLZVQXDP-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50133824   

LigandPNGBDBM50133824(4-(3-Cyano-pyridin-2-yl)-piperazine-1-carboxylic a...)
Affinity DataIC50: 2.50E+4nMAssay Description:Vanilloid receptor subtype 1 antagonist activity based on its ability to block capsaicin-induced (CAP) activation of the rat VR1 channel in a HEK293 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50133824(4-(3-Cyano-pyridin-2-yl)-piperazine-1-carboxylic a...)
Affinity DataIC50: 287nMAssay Description:Vanilloid receptor subtype 1 antagonist activity based on its ability to block capsaicin-induced (CAP) activation of the rat VR1 channel in a HEK293 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPantothenate kinase 3(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50133824(4-(3-Cyano-pyridin-2-yl)-piperazine-1-carboxylic a...)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of human recombinant N-terminal His6-fusion tagged PanK3 expressed in Escherichia coli BL21 (DE3) measured after 10 mins in presence of AT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed