BDBM50132901 CHEMBL445075::Cyclopropylmethyl-[3-(2,4-dichloro-phenyl)-1,5-dimethyl-1H-pyrazolo[4,3-b]pyridin-7-yl]-propyl-amine

SMILES CCCN(CC1CC1)c1cc(C)nc2c(nn(C)c12)-c1ccc(Cl)cc1Cl

InChI Key InChIKey=GNYSGPZMUULBMF-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50132901   

TargetCorticotropin-releasing factor receptor 1(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50132901(Cyclopropylmethyl-[3-(2,4-dichloro-phenyl)-1,5-dim...)
Affinity DataIC50: 5nMAssay Description:Compound was tested to inhibit Corticotropin releasing factor receptor 1-stimulated c-AMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50132901(Cyclopropylmethyl-[3-(2,4-dichloro-phenyl)-1,5-dim...)
Affinity DataIC50: 16nMAssay Description:Inhibition of (Corticotropin-Releasing Factor Receptor) CRF-stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50132901(Cyclopropylmethyl-[3-(2,4-dichloro-phenyl)-1,5-dim...)
Affinity DataKi:  1.70nMAssay Description:Compound was tested to inhibit Corticotropin releasing factor receptor 1-stimulated c-AMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50132901(Cyclopropylmethyl-[3-(2,4-dichloro-phenyl)-1,5-dim...)
Affinity DataKi:  1.70nMAssay Description:Inhibition of (Corticotropin-Releasing Factor Receptor) CRF-stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed