BDBM50132892 Butyl-[3-(2,4-dichloro-phenyl)-1,5-dimethyl-1H-pyrazolo[4,3-b]pyridin-7-yl]-ethyl-amine::CHEMBL111665

SMILES CCCCN(CC)c1cc(C)nc2c(nn(C)c12)-c1ccc(Cl)cc1Cl

InChI Key InChIKey=ZFHZGWQWYGSYFW-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50132892   

TargetCorticotropin-releasing factor receptor 1(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50132892(Butyl-[3-(2,4-dichloro-phenyl)-1,5-dimethyl-1H-pyr...)
Affinity DataIC50: 16nMAssay Description:Compound was tested to inhibit Corticotropin releasing factor receptor 1-stimulated c-AMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50132892(Butyl-[3-(2,4-dichloro-phenyl)-1,5-dimethyl-1H-pyr...)
Affinity DataIC50: 16nMAssay Description:Inhibition of Corticotropin releasing factor receptor 1-stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50132892(Butyl-[3-(2,4-dichloro-phenyl)-1,5-dimethyl-1H-pyr...)
Affinity DataKi:  2nMAssay Description:Binding affinity to the human corticotropin releasing factor receptor 1 expressed in HEK273 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50132892(Butyl-[3-(2,4-dichloro-phenyl)-1,5-dimethyl-1H-pyr...)
Affinity DataKi:  2nMAssay Description:Binding affinity towards Corticotropin releasing factor receptor 1 was measured through displacement of [125I]sauvagine expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed