BDBM50132636 (2R,3S)-4-Acetyl-1-[4-(3,5-difluoro-benzyloxy)-benzenesulfonyl]-3-methyl-piperazine-2-carboxylic acid hydroxyamide::CHEMBL111862

SMILES C[C@H]1[C@@H](N(CCN1C(C)=O)S(=O)(=O)c1ccc(OCc2cc(F)cc(F)c2)cc1)C(=O)NO

InChI Key InChIKey=RCOBSDNFRJAUBV-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50132636   

TargetInterstitial collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50132636((2R,3S)-4-Acetyl-1-[4-(3,5-difluoro-benzyloxy)-ben...)
Affinity DataIC50: 3.80E+3nMAssay Description:In vitro inhibition of matrix metalloprotease-1.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50132636((2R,3S)-4-Acetyl-1-[4-(3,5-difluoro-benzyloxy)-ben...)
Affinity DataIC50: 20nMAssay Description:In vitro inhibition of matrix metalloprotease-13.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50132636((2R,3S)-4-Acetyl-1-[4-(3,5-difluoro-benzyloxy)-ben...)
Affinity DataIC50: 6nMAssay Description:Inhibition of human recombinant tumor necrosis factor-alpha converting enzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50132636((2R,3S)-4-Acetyl-1-[4-(3,5-difluoro-benzyloxy)-ben...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of Tumor necrosis factor-alpha (TNF-alpha) release in human whole bloodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed