BDBM50132629 (2R,3S)-4-Acetyl-1-[4-(isoquinolin-4-ylmethoxy)-benzenesulfonyl]-3-methyl-piperazine-2-carboxylic acid hydroxyamide::CHEMBL111475

SMILES C[C@H]1[C@@H](N(CCN1C(C)=O)S(=O)(=O)c1ccc(OCc2cncc3ccccc23)cc1)C(=O)NO

InChI Key InChIKey=GIJWOCNEPGCMND-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50132629   

TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50132629((2R,3S)-4-Acetyl-1-[4-(isoquinolin-4-ylmethoxy)-be...)
Affinity DataIC50: 98nMAssay Description:In vitro inhibition of matrix metalloprotease-13.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50132629((2R,3S)-4-Acetyl-1-[4-(isoquinolin-4-ylmethoxy)-be...)
Affinity DataIC50: 400nMAssay Description:Inhibition of human recombinant tumor necrosis factor-alpha converting enzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50132629((2R,3S)-4-Acetyl-1-[4-(isoquinolin-4-ylmethoxy)-be...)
Affinity DataIC50: 6.40E+3nMAssay Description:In vitro inhibition of matrix metalloprotease-1.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed