BDBM50132490 CHEMBL3633928

SMILES NC(=O)Nc1ccc2ncnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2c1

InChI Key InChIKey=HUROJPARIBKVDY-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50132490   

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Korea University of Science and Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50132490(CHEMBL3633928)
Affinity DataIC50: 287nMAssay Description:Inhibition of HER2 (unknown origin) after 120 mins by HotSpot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2016
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Korea University of Science and Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50132490(CHEMBL3633928)
Affinity DataIC50: 99nMAssay Description:Inhibition of EGFR (unknown origin) after 120 mins by HotSpot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2016
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Korea University of Science and Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50132490(CHEMBL3633928)
Affinity DataIC50: 27nMAssay Description:Inhibition of His-tagged human recombinant Her2 (676 to 1255 residues) expressed in baculovirus by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2017
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Korea University of Science and Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50132490(CHEMBL3633928)
Affinity DataIC50: 186nMAssay Description:Inhibition of wild type EGFR (unknown origin) expressed in mouse BaF/3 cells assessed as cell growth inhibition after 72 hrs by MTS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2017
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50132490(CHEMBL3633928)
Affinity DataIC50: 407nMAssay Description:Inhibition of EGFR L858R mutant (unknown origin) expressed in mouse BaF/3 cells assessed as cell growth inhibition after 72 hrs by MTS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2017
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Korea University of Science and Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50132490(CHEMBL3633928)
Affinity DataIC50: 2nMAssay Description:Inhibition of recombinant human EGFR expressed in baculovirus by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2017
Entry Details Article
PubMed