BDBM50132478 CHEMBL3634609::US9751873, Example 157

SMILES [H][C@@]12CN(C[C@]1([H])[C@H]2n1cnnc1)c1cc(F)c(CN2CCCC[C@@H](c3ccccc3)S2(=O)=O)cc1F

InChI Key InChIKey=LVDLDLNTZZPHDL-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50132478   

TargetNuclear receptor ROR-gamma(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50132478(CHEMBL3634609 | US9751873, Example 157)
Affinity DataIC50: 5nMAssay Description:Displacement of 25-[3H]hydroxycholesterol from N-terminal 6xHis-GST-tagged human RORc ligand binding domain expressed in Escherichia coli after 3 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2016
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50132478(CHEMBL3634609 | US9751873, Example 157)
Affinity DataIC50: 5nMAssay Description:Assays were carried out in 16-microL reaction volumes in black 384 Plus F Proxiplates (Perkin-Elmer 6008269). All assay components except test ligand...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2019
Entry Details
Go to US Patent

TargetNuclear receptor ROR-gamma(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50132478(CHEMBL3634609 | US9751873, Example 157)
Affinity DataIC50: 5nMAssay Description:Assays were carried out in 16-microL reaction volumes in black 384 Plus F Proxiplates (Perkin-Elmer 6008269). All assay components except test ligand...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2019
Entry Details
Go to US Patent