BDBM50132477 CHEMBL3632716::US9751873, Example 127

SMILES C[C@H]1CC[C@H](c2ccccc2)S(=O)(=O)N1Cc1cc(F)c(cc1F)C(CO)CC1COC1

InChI Key InChIKey=ILKCLQBCDOSHSH-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50132477   

TargetNuclear receptor ROR-gamma(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50132477(CHEMBL3632716 | US9751873, Example 127)
Affinity DataIC50: 4nMAssay Description:Displacement of 25-[3H]hydroxycholesterol from N-terminal 6xHis-GST-tagged human RORc ligand binding domain expressed in Escherichia coli after 3 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2016
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50132477(CHEMBL3632716 | US9751873, Example 127)
Affinity DataIC50: 4nMAssay Description:Assays were carried out in 16-microL reaction volumes in black 384 Plus F Proxiplates (Perkin-Elmer 6008269). All assay components except test ligand...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2019
Entry Details
Go to US Patent

TargetNuclear receptor ROR-gamma(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50132477(CHEMBL3632716 | US9751873, Example 127)
Affinity DataIC50: 7nMAssay Description:Assays were carried out in 16-microL reaction volumes in black 384 Plus F Proxiplates (Perkin-Elmer 6008269). All assay components except test ligand...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2019
Entry Details
Go to US Patent